Eukaryotes possess promoter and termination regions that are largely nucleosome free. Nucleosomes are positioned at canonical distances from the transcription start site (TSS). In Saccharomyces ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes.

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone ...

Tokyo, April 14 - A research group led by Hitoshi Kurumizaka, a professor of structural biology at Waseda University, unveiled the crystal structure of an overlapping dinucleosome, a newly discovered ...

Individual cells divide through a process called mitosis, during which the cell's copied DNA is separated between two resulting daughter cells. Despite recent advances in cell biology, the mechanism ...

Researchers at the University of California San Diego say they have identified a key factor that partially unravels nucleosomes and thus opens the way for genes to activate. The identification of NDF, ...

The eukaryotic genome can be up to 130 billion base pairs long, but required to fit inside each cell nucleus. To do this, DNA is tightly wrapped around histone proteins in bead-like clusters. Each ...

Researchers at The University of Texas MD Anderson Cancer Center have shown that DNA inflexibility, or rigidity, inside the nucleosome regulates the positioning of INO80. This highlights that the ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes.